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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
TIE1
All Species:
22.42
Human Site:
Y1083
Identified Species:
44.85
UniProt:
P35590
Number Species:
11
Phosphosite Substitution
Charge Score:
0.09
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P35590
NP_005415.1
1138
125090
Y1083
R
N
C
D
D
E
V
Y
E
L
M
R
Q
C
W
Chimpanzee
Pan troglodytes
XP_001173341
1138
125051
Y1083
R
N
C
D
D
E
V
Y
E
L
M
R
Q
C
W
Rhesus Macaque
Macaca mulatta
XP_001090483
1164
128010
Y1109
R
N
C
D
D
E
V
Y
E
L
M
R
Q
C
W
Dog
Lupus familis
XP_539652
1239
135146
Y1184
R
N
C
D
D
E
V
Y
E
L
M
R
Q
C
W
Cat
Felis silvestris
Mouse
Mus musculus
Q06806
1134
124680
Y1079
R
N
C
D
D
E
V
Y
E
L
M
R
Q
C
W
Rat
Rattus norvegicus
Q498D6
800
88690
L753
L
A
V
S
E
E
Y
L
D
L
R
L
T
F
G
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001512741
1077
116365
V1021
S
L
P
C
P
D
E
V
Y
E
L
M
N
Q
C
Chicken
Gallus gallus
P18460
806
89712
V759
D
E
Y
L
D
L
S
V
P
F
E
Q
Y
S
P
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
O73791
1116
122343
Y1060
L
N
C
D
D
E
V
Y
E
L
M
Q
Q
C
W
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q9VBW3
773
86202
H726
I
M
Y
Y
C
W
S
H
D
P
Q
E
R
P
L
Honey Bee
Apis mellifera
XP_396649
796
90178
E749
P
M
F
G
E
L
V
E
D
L
D
R
I
L
T
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
Q26614
972
110463
L925
V
S
S
N
Q
D
Y
L
D
L
E
A
V
G
D
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.6
95.1
85.6
N.A.
92.5
25.8
N.A.
65.9
25.1
N.A.
44.6
N.A.
22.4
24.7
N.A.
22.8
Protein Similarity:
100
99.8
96.2
88.1
N.A.
95.5
37.9
N.A.
74.3
39.3
N.A.
58.7
N.A.
36
40.3
N.A.
39.1
P-Site Identity:
100
100
100
100
N.A.
100
13.3
N.A.
0
6.6
N.A.
86.6
N.A.
0
20
N.A.
6.6
P-Site Similarity:
100
100
100
100
N.A.
100
26.6
N.A.
13.3
13.3
N.A.
93.3
N.A.
20
33.3
N.A.
33.3
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
9
0
0
0
0
0
0
0
0
0
9
0
0
0
% A
% Cys:
0
0
50
9
9
0
0
0
0
0
0
0
0
50
9
% C
% Asp:
9
0
0
50
59
17
0
0
34
0
9
0
0
0
9
% D
% Glu:
0
9
0
0
17
59
9
9
50
9
17
9
0
0
0
% E
% Phe:
0
0
9
0
0
0
0
0
0
9
0
0
0
9
0
% F
% Gly:
0
0
0
9
0
0
0
0
0
0
0
0
0
9
9
% G
% His:
0
0
0
0
0
0
0
9
0
0
0
0
0
0
0
% H
% Ile:
9
0
0
0
0
0
0
0
0
0
0
0
9
0
0
% I
% Lys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% K
% Leu:
17
9
0
9
0
17
0
17
0
75
9
9
0
9
9
% L
% Met:
0
17
0
0
0
0
0
0
0
0
50
9
0
0
0
% M
% Asn:
0
50
0
9
0
0
0
0
0
0
0
0
9
0
0
% N
% Pro:
9
0
9
0
9
0
0
0
9
9
0
0
0
9
9
% P
% Gln:
0
0
0
0
9
0
0
0
0
0
9
17
50
9
0
% Q
% Arg:
42
0
0
0
0
0
0
0
0
0
9
50
9
0
0
% R
% Ser:
9
9
9
9
0
0
17
0
0
0
0
0
0
9
0
% S
% Thr:
0
0
0
0
0
0
0
0
0
0
0
0
9
0
9
% T
% Val:
9
0
9
0
0
0
59
17
0
0
0
0
9
0
0
% V
% Trp:
0
0
0
0
0
9
0
0
0
0
0
0
0
0
50
% W
% Tyr:
0
0
17
9
0
0
17
50
9
0
0
0
9
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _